Excitatory amino acids and Alzheimer's disease.

  title={Excitatory amino acids and Alzheimer's disease.},
  author={J Timothy Greenamyre and Anne B. Young},
  journal={Neurobiology of aging},
  volume={10 5},
Excitatory amino acids (EAA) such as glutamate and aspartate are major transmitters of the cerebral cortex and hippocampus, and EAA mechanisms appear to play a role in learning and memory. Anatomical and biochemical evidence suggests that there is both pre- and postsynaptic disruption of EAA pathways in Alzheimer's disease. Dysfunction of EAA pathways could… CONTINUE READING