Excitatory amino acid response in cultured rat striatal neurons results in a developmentally regulated cGMP formation

@article{Novelli1993ExcitatoryAA,
  title={Excitatory amino acid response in cultured rat striatal neurons results in a developmentally regulated cGMP formation},
  author={Antonello Novelli and Umberto di Porzio},
  journal={International Journal of Developmental Neuroscience},
  year={1993},
  volume={11},
  pages={425-434}
}
Glutamate and its analogues play a central role in excitatory neurotransmission throughout the brain. Their signal in the postsynaptic cells can be transduced by several second messengers. Here we show that in primary cultures of embryonic rat striatum, excitatory amino acid receptor stimulation increases cyclic GMP intracellular concentration and the magnitude of this response depends upon the time in culture. Formation of cyclic GMP appears to be mediated by both N-methyl-D-aspartate (NMDA… CONTINUE READING

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