Excitatory amino acid modulation of lordosis in the rat.

  title={Excitatory amino acid modulation of lordosis in the rat.},
  author={M M McCarthy and G H Curran and H H Feder},
  journal={Neuroscience letters},
  volume={126 1},
Microinfusion of the excitatory amino acid agonist N-methyl-D-aspartate (NMDA) into the mediobasal hypothalamus (MBH) significantly reduced lordosis in estrogen plus progesterone-treated female rats at 10 min post-infusion with recovery to pretest values by 30 min (P less than .05; Wilcoxon). Microinfusion of the specific NMDA antagonist D,L2-amino-5-phosphonopentoic acid (AP-5) into the same sites was without effect on lordosis responding of fully receptive females. There was also a… CONTINUE READING