Excitatory actions of gaba during development: the nature of the nurture

@article{BenAri2002ExcitatoryAO,
  title={Excitatory actions of gaba during development: the nature of the nurture},
  author={Yehezkel Ben-Ari},
  journal={Nature Reviews Neuroscience},
  year={2002},
  volume={3},
  pages={728-739}
}
  • Y. Ben-Ari
  • Published 1 September 2002
  • Biology
  • Nature Reviews Neuroscience
In the immature brain, GABA (γ-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially… 
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