Excitatory actions of gaba during development: the nature of the nurture

@article{BenAri2002ExcitatoryAO,
  title={Excitatory actions of gaba during development: the nature of the nurture},
  author={Yehezkel Ben-Ari},
  journal={Nature Reviews Neuroscience},
  year={2002},
  volume={3},
  pages={728-739}
}
  • Y. Ben-Ari
  • Published 2002
  • Biology, Medicine
  • Nature Reviews Neuroscience
In the immature brain, GABA (γ-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially… Expand
Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons
TLDR
This paper focuses on brainstem and spinal motoneurons that are largely targeted by GABAergic interneurons, and brings together data on the switch from excitatory to inhibitory effects of GABA, on the maturation of the GABAergic system and GABAAR subunits. Expand
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
TLDR
This review considers the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability in the adult mammalian brain. Expand
Sequential Interplay of Nicotinic and GABAergic Signaling Guides Neuronal Development
TLDR
It is shown here that spontaneous nicotinic cholinergic activity is responsible for terminating GABAergic excitation and initiating inhibition, and the results reveal a multitiered activity-dependent strategy controlling neuronal development. Expand
GABA Generates Excitement
TLDR
The evolving story on chloride ion homeostasis in CNS neurons and its role in the bipolar life of the GABA(A) receptor is discussed. Expand
Is there more to gaba than synaptic inhibition?
TLDR
The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal in the immature brain. Expand
GABA | GABA Excites Immature Neurons: Implications for the Epilepsies
TLDR
GABA is important for high incidence of seizures in the developing brain, and agents that reduce [Cl−]i also reduce seizures, and drugs that alter GABA activity – including antiepileptic agents – may produce deleterious sequelae. Expand
An excitatory GABA loop operating in vivo
TLDR
The results imply that elevated chloride concentration can occur in specific intracellular compartments of mature mammalian neurons and suggest an excitatory role for GABAA receptors in the cerebellar cortex of adult mice. Expand
The GABA developmental shift in health and disease
TLDR
Restoring GABAergic inhibition and the polarity of GABA actions is a promising novel therapeutic avenue and recent clinical trials in the treatment of autism spectrum disorders have validated the importance of this approach. Expand
Development of the GABAergic System from Birth to Adolescence
  • W. Kilb
  • Biology, Medicine
  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2012
TLDR
This review summarizes recent knowledge of the maturation of various aspects of the GABAergic systems, like functional expression of GABA synthesizing/degrading enzymes and transporters, density of GABAergic synapses, GABAergic projection patterns, GABA receptor subunit composition, and properties ofGAergic interneurons, with an emphasis on the late developmental alterations. Expand
Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions
γ-Aminobutyric acid (GABA) evokes excitation in the immature brain, but induces inhibition in the adult. Excitatory GABA actions are necessary for neurogenesis, differentiation, migration, andExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 140 REFERENCES
GABA Itself Promotes the Developmental Switch of Neuronal GABAergic Responses from Excitation to Inhibition
TLDR
GABA acts as a self-limiting trophic factor during neural development by modulating the mRNA levels of KCC2, a K(+)-Cl(-) cotransporter whose expression correlates with the switch. Expand
GABA is the principal fast-acting excitatory transmitter in the neonatal brain.
TLDR
GDPs provide synchronous intracellular Ca2+ oscillations and may be implicated in hebbian modulation of developing synapses and activity-dependent formation of the hippocampal network and they are mediated by the synergistic excitatory actions of GABAA and glutamate receptors. Expand
Is there more to gaba than synaptic inhibition?
TLDR
The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal in the immature brain. Expand
Physiological functions of GABA-induced depolarizations in the developing rat spinal cord.
TLDR
It is proposed that despite its depolarizing action, GABA acts as an inhibitory neurotransmitter that may also function as a neurotrophic agent. Expand
GABAB receptor-mediated regulation of glutamate-activated calcium transients in hypothalamic and cortical neuron development.
TLDR
Ca2+ digital imaging data suggest both a pre- and postsynaptic component for the modulatory actions of the GABAB receptor as a modulator of the excitatory actions of glutamate in developing neurons. Expand
GABAA, NMDA and AMPA receptors: a developmentally regulated `ménage à trois'
TLDR
Determining the mechanisms underlying the development of this 'ménage à trois' will shed light not only on the wide range of trophic roles of glutamate and GABA in the developing brain, but also on the significance of the transition from neonatal to adult forms of plasticity. Expand
GABA-dependent firing of glutamate-evoked action potentials at AMPA/kainate receptors in developing hypothalamic neurons.
TLDR
Results obtained in the presence of 2-amino-5-phosphonopentanoic acid indicate that GABA can facilitate glutamate responses independent of relief of the Mg2+ block of the N-methyl-D-aspartate (NMDA) receptor. Expand
Mechanisms of Induction and Expression of Long-Term Depression at GABAergic Synapses in the Neonatal Rat Hippocampus
TLDR
It is reported that the induction of LTDGABA-A requires a GABAA receptor-mediated membrane depolarization, which is necessary to remove the Mg2+ block from postsynaptic NMDA receptors. Expand
GABA, not glutamate, a primary transmitter driving action potentials in developing hypothalamic neurons.
TLDR
It is reported that during early development, synaptic release of GABA, the primary inhibitory neurotransmitter in the mature brain, is not only excitatory but in addition plays a more robust role than glutamate in generating spike activity in mouse hypothalamic neurons. Expand
NMDA receptor activation limits the number of synaptic connections during hippocampal development
TLDR
It is shown that chronic blockade of NMDA receptors in hippocampal slice cultures during the first two weeks of postnatal development leads to a substantial increase in synapse number and results in a more complex dendritic arborization of CA1 pyramidal cells. Expand
...
1
2
3
4
5
...