Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus.

In the developing rat hippocampus, ictal epileptiform activity can be elicited easily in vitro during the first three postnatal weeks. Changes in neuronal ion transport during this time cause the effects of GABA(A) receptor (GABA(A)-R) activation to shift gradually from strongly depolarizing to hyperpolarizing. It is not known whether the depolarizing… CONTINUE READING