Excitatory actions of GABA after neuronal trauma.

  title={Excitatory actions of GABA after neuronal trauma.},
  author={Anthony N van den Pol and Karl Obrietan and Gong Chen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={16 13},
GABA is the dominant inhibitory neurotransmitter in the CNS. By opening Cl- channels, GABA generally hyperpolarizes the membrane potential, decreases neuronal activity, and reduces intracellular Ca2+ of mature neurons. In the present experiment, we show that after neuronal trauma, GABA, both synaptically released and exogenously applied, exerted a novel and opposite effect, depolarizing neurons and increasing intracellular Ca2+. Different types of trauma that were effective included neurite… CONTINUE READING
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Growth cone calcium rise evoked by GABA

  • J Olney, L Sharpe
  • J Comp Neurol
  • 1996

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