Excitatory Projection Neuron Subtypes Control the Distribution of Local Inhibitory Interneurons in the Cerebral Cortex

@article{Lodato2011ExcitatoryPN,
  title={Excitatory Projection Neuron Subtypes Control the Distribution of Local Inhibitory Interneurons in the Cerebral Cortex},
  author={Simona Lodato and Caroline Rouaux and Kathleen B. Quast and Chanati Jantrachotechatchawan and Mich{\`e}le Studer and Takao K Hensch and Paola Arlotta},
  journal={Neuron},
  year={2011},
  volume={69},
  pages={763-779}
}
In the mammalian cerebral cortex, the developmental events governing the integration of excitatory projection neurons and inhibitory interneurons into balanced local circuitry are poorly understood. We report that different subtypes of projection neurons uniquely and differentially determine the laminar distribution of cortical interneurons. We find that in Fezf2⁻/⁻ cortex, the exclusive absence of subcerebral projection neurons and their replacement by callosal projection neurons cause… CONTINUE READING
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