Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats.

@article{Kim2018ExcitatoryGA,
  title={Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats.},
  author={Young-Beom Kim and Woong Bin Kim and Won Woo Jung and Xiangyan Jin and Yoon Sik Kim and Byoungjae Kim and Hee Chul Han and Gene D. Block and Christopher S Colwell and Yang In Kim},
  journal={Diabetes},
  year={2018},
  volume={67 3},
  pages={486-495}
}
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices from streptozotocin (STZ)-induced DM rats and vehicle-treated control rats revealed that γ-aminobutyric acid (GABA) functions generally as an excitatory neurotransmitter in the AVP neurons of STZ… CONTINUE READING
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