Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits

@article{Szabadics2006ExcitatoryEO,
  title={Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits},
  author={J{\'a}nos Szabadics and Csaba Varga and G{\'a}bor Moln{\'a}r and Szabolcs Ol{\'a}h and P{\'a}l Barz{\'o} and G{\'a}bor Tam{\'a}s},
  journal={Science},
  year={2006},
  volume={311},
  pages={233 - 235}
}
Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from γ-aminobutyric acid–releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks… Expand
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TLDR
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Neurophysiology: Cause for excitement
  • A. Rowan
  • Biology
  • Nature Reviews Neuroscience
  • 2006
TLDR
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TLDR
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TLDR
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TLDR
The results imply that elevated chloride concentration can occur in specific intracellular compartments of mature mammalian neurons and suggest an excitatory role for GABAA receptors in the cerebellar cortex of adult mice. Expand
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