Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning

@inproceedings{Gao2016ExcitatoryCN,
  title={Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning},
  author={Zhenyu Gao and Martina Proietti-Onori and Zhanmin Lin and Michiel M. ten Brinke and H. J. Boele and J W Potters and Tom J H Ruigrok and Freek E Hoebeek and Chris I. De Zeeuw},
  booktitle={Neuron},
  year={2016}
}
Closed-loop circuitries between cortical and subcortical regions can facilitate precision of output patterns, but the role of such networks in the cerebellum remains to be elucidated. Here, we characterize the role of internal feedback from the cerebellar nuclei to the cerebellar cortex in classical eyeblink conditioning. We find that excitatory output neurons in the interposed nucleus provide efference-copy signals via mossy fibers to the cerebellar cortical zones that belong to the same… CONTINUE READING
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