Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

@article{Bateup2013ExcitatoryInhibitorySI,
  title={Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis},
  author={Helen S Bateup and Caroline A. Johnson and Cassandra L. Denefrio and Jessica Lizette Saulnier and Karl Kornacker and Bernardo L. Sabatini},
  journal={Neuron},
  year={2013},
  volume={78},
  pages={510-522}
}
Neural circuits are regulated by activity-dependent feedback systems that tightly control network excitability and which are thought to be crucial for proper brain development. Defects in the ability to establish and maintain network homeostasis may be central to the pathogenesis of neurodevelopmental disorders. Here, we examine the function of the tuberous sclerosis complex (TSC)-mTOR signaling pathway, a common target of mutations associated with epilepsy and autism spectrum disorder, in… CONTINUE READING
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