Excitation of rat cutaneous nociceptors by noxious cold

@article{Simone1996ExcitationOR,
  title={Excitation of rat cutaneous nociceptors by noxious cold},
  author={Donald A. Simone and Keith C. Kajander},
  journal={Neuroscience Letters},
  year={1996},
  volume={213},
  pages={53-56}
}
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109 Citations
Highly Influential Citations
10
Background Citations
52
Methods Citations
5
Results Citations
3

109 Citations

Responses of cutaneous A-fiber nociceptors to noxious cold.

It is concluded that the proportion of cutaneous A delta-nociceptors excited by noxious cold stimuli has been underestimated in previous studies and is likely to contribute to the sensation of cold pain, particularly pain produced by stimulus temperatures <0 degrees C.

C-nociceptors sensitized to cold in a patient with small-fiber neuropathy and cold allodynia

Unmyelinated afferents in human skin and their responsiveness to low temperature

Threshold and rate sensitivity of low‐threshold thermal nociception

The results of both experiments are consistent with the mediation of LTN by low‐threshold thermoreceptors, although LTN caused by heating may depend on a subset of fibers that express less sensitive TRP channels than those that serve sensations of warmth at the mildest temperatures.

Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs.

The results of the present study suggest that the model of acetic acid-induced nociception in frogs may be useful for studying the mechanisms by which tissue acidosis produces pain.

Capsaicin-sensitive primary afferents mediate responses to cold in rats with a peripheral mononeuropathy

The results demonstrate that the enhanced responsiveness to cold and heat following a CCI are mediated in part by RTX-sensitive primary afferents.

Thermoreceptors and thermosensitive afferents

Skin cooling attenuates rat dorsal horn neuronal responses to intracutaneous histamine

It is shown that lowering skin temperature attenuates responses of spinal dorsal horn neurons elicited by intracutaneous microinjection of histamine in anesthetized rats, which may account for the psychophysical observation that skin cooling relieves itch in humans.

Spinal Processing of Noxious and Innocuous Cold Information: Differential Modulation by the Periaqueductal Gray

It is demonstrated that spinal responses to cold can be powerfully modulated by descending control systems originating from the periaqueductal gray (PAG), and that this control selectively modulates transmission of noxious versus innocuous information.

Responses of C-fiber low threshold mechanoreceptors and nociceptors to cold were facilitated in rats persistently inflamed and hypersensitive to cold

...

References

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Response properties of high-threshold cutaneous cold receptors in the primate

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The dynamic responses were characterized by three phases: an initiation of a discharge at a threshold level of skin temperature; a dynamic discharge during the suprathreshold change, that reached a peak frequency when the temperature reached its maximum; and an adaptation phase while the temperature remained at the high intensity.

Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to monkey's face

The analysis revealed that the discharge of C polymodal nociceptors alone cannot account for fast escape responses, but the discharge may contribute to escape responses which occur more than 3.5 s after the onset of stimulation, and linear regression analyses showed that most units examined were best fit by nonlinear functions.

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

In an attempt to learn more about the range of behavior associated with the terminals of cutaneous C fibers, a number of randomly sele,cted units were surveyed for responses to a variety of graded stimuli.

A peripheral "cold" fiber population responsive to innocuous and noxious thermal stimuli applied to monkey's face.

The activity of 134 cold fibers innervating the hairy skin of the face was recorded from fine dissected strands of the infraorbital nerve in rhesus monkeys anesthetized with sodium pentobarbital to produce rapid temperature shifts in the cooling and warming directions.

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Although information from sense organs is used by all animals, only man can verbally report his sensory experience, and neurophysiological experiments defining the properties of cutaneous sense organs have most often been done on animals other than man.

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High-threshold primary afferent units were selected from the population of axons functionally isolated in fine filaments dissected from the median and ulnar nerves of macaque monkeys to study their responses to mechanical and thermal stimuli applied to their receptive fiblds in the glabrous skin of the hand.

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Eleven patients with sustained neuralgia, in most cases after traumatic nerve lesion, were subjected to quantitative sensory testing with thermal and non-noxious mechanical stimuli, indicating hypersensitivity of the nociceptor system or dysaesthesia for thermal input.

Sensibility Abnormalities in Neuralgic Patients Studied by Thermal and Tactile Pulse Stimulation

Six patients with neuralgia and disturbed thermosensibility were examined with graded thermal and mechanical pulses which suggest that pulsed natural stimuli may be valuable in further analyses of the mechanisms of sensory dysfunction and pain, and possibly also in clinical evaluation.

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The present experiments were done to learn more of the sensory functions of the non-myelinated afferent fibres in cutaneous nerves by studying their electrical activity and examining whether or not they signal changes in skin temperature.