Excitation of rat cutaneous nociceptors by noxious cold.


Electrophysiological recordings were made from mechanosensitive nociceptors innervating hairy skin of the rat hindpaw, and responses evoked by a wide range of noxious cold stimuli (20 to -12 degrees C) were determined. All A delta and C nociceptors sampled were excited by noxious cold. Response thresholds of A delta nociceptors were significantly higher… (More)


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