Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.

@article{Botta2012ExcitationOR,
  title={Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.},
  author={Paolo Botta and Fabio M Sim{\~o}es de Souza and Thomas Sangrey and Erik De Schutter and C F Valenzuela},
  journal={Alcoholism, clinical and experimental research},
  year={2012},
  volume={36 4},
  pages={616-24}
}
BACKGROUND Studies with rodents suggest that acute ethanol exposure impairs information flow through the cerebellar cortex, in part, by increasing GABAergic input to granule cells. Experiments suggest that an increase in the excitability of specialized GABAergic interneurons that regulate granule cell activity (i.e., Golgi cells [GoCs]) contributes to this effect. In GoCs, ethanol increases spontaneous action potential firing frequency, decreases the afterhyperpolarization amplitude, and… CONTINUE READING
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