Excitation of locus coeruleus neurons by vasoactive intestinal peptide: role of a cAMP and protein kinase A.

@article{Wang1990ExcitationOL,
  title={Excitation of locus coeruleus neurons by vasoactive intestinal peptide: role of a cAMP and protein kinase A.},
  author={Yunling Wang and George Kevork Aghajanian},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1990},
  volume={10 10},
  pages={
          3335-43
        }
}
In accord with previous studies, it was found that vasoactive intestinal peptide (VIP), a powerful activator of adenylate cyclase, and cAMP-active agents (i.e., 8-Br-cAMP, forskolin, and Ro20-1724) increased the firing rate of noradrenergic neurons in the locus coeruleus (LC) by inducing an inward current. The response to VIP was usually more rapid and larger in a subpopulation of LC neurons with subthreshold rhythmic oscillations in membrane potential (oscillatory cells) as compared to… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

An inhibitor of CAMP-dependent protein kinase blocks the activation of rat locus coeruleus cell firing induced by 8-Br-CAMP, forskolin, and Ro20- 1724

Wang Y-Y, GK Aghajanian
  • Sot Neurosci Abstr
  • 1989

An inhibitor of CAMP-dependent protein kinase blocks the activation of rat locus coeruleus cell firing induced by 8-Br-CAMP, forskolin, and Ro20- 1724

Wang Y-Y, GK Aghajanian
  • Sot Neurosci Abstr
  • 1989

Electrical counlina svnchronizes’subthreshold’activity in locus coeruleus neurons il v&o from neonatal rats

JT ChristieMJ.Williams, RA North
  • J Neurosci
  • 1989

Protein kinase inhibitors selectively block phorbol ester- or forskolin-induced changes in excitability of Aplysia neurons.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
VIEW 1 EXCERPT