Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms

@article{Hilgemann1987ExcitationcontractionCA,
  title={Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms},
  author={Donald W Hilgemann and Denis Noble},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1987},
  volume={230},
  pages={163 - 205}
}
  • D. Hilgemann, D. Noble
  • Published 1987
  • Chemistry, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
Interactions of electrogenic sodium-calcium exchange, calcium channel and sarcoplasmic reticulum in the mammalian heart have been explored by simulation of extracellular calcium transients measured with tetramethylmurexide in rabbit atrium. The approach has been to use the simplest possible formulations of these mechanisms, which together with a minimum number of additional mechanisms allow reconstruction of action potentials, intracellular calcium transients and extracellular calcium… Expand
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  • W. Ho, Y. Earm
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
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TLDR
The nonlinear relation between the inward current and the calcium current strongly supports the regenerative Ca release hypothesis of the calcium-induced calcium release (CICR) mechanism and such regenerative behavior was abolished by a high concentration of Ca buffer or premature stimulation. Expand
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In adult cardiomyocytes, the established mechanism of excitation-contraction coupling is calcium-induced calcium release (CICR) mediated by L-type Ca channels (Cav1.2). Briefly, membraneExpand
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  • D. Noble
  • Chemistry, Medicine
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  • 2005
TLDR
Modelling of this process in equations developed recently with Dario DiFrancesco, Susan Noble and Don Hilgemann succeeds in reproducing both the ionic current changes and the fast extracellular calcium transients. Expand
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  • 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 1992
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  • Y. Earm, D. Noble
  • Chemistry, Medicine
  • Proceedings of the Royal Society of London. B. Biological Sciences
  • 1990
TLDR
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The purpose of the present paper is to review the evidence, experimental and theoretical, for a major role of the sodium-calcium exchange current during normal cardiac rhythm. Expand
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  • Chemistry, Medicine
  • Biophysical journal
  • 1992
TLDR
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TLDR
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TLDR
Both Ca current and membrane currents related to Ca-entry during activation ofICa have been studied in cultured atrial myocytes from hearts of adult guinea pigs, suggesting both current changes to be caused by a rise in Cai due to Ca release from sarcoplasmic reticulum. Expand
Control of the Na-Ca exchanger in isolated heart cells. I. Induction of Na-Na exchange in sodium-loaded cells by intracellular calcium.
TLDR
It is concluded 1) that intracellular calcium induces Na-Na exchange through the Na-Ca exchanger in sodium-loaded cells exposed to calcium; and 2) that Na- Na exchange can be activated by calcium that enters the cell through calcium channels, and it is proposed that this Na- na exchange reflects the intrinsic activity of theNa- Ca exchanger. Expand
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