Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice.

@article{English2014ExcitationAI,
  title={Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice.},
  author={Daniel F English and Adrien Peyrache and Eran Stark and Lisa Roux and Daniela Vallentin and Michael A. Long and Gy{\"o}rgy Buzs{\'a}ki},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 49},
  pages={16509-17}
}
High-frequency ripple oscillations, observed most prominently in the hippocampal CA1 pyramidal layer, are associated with memory consolidation. The cellular and network mechanisms underlying the generation of the rhythm and the recruitment of spikes from pyramidal neurons are still poorly understood. Using intracellular, sharp electrode recordings in freely moving, drug-free mice, we observed consistent large depolarizations in CA1 pyramidal cells during sharp wave ripples, which are associated… CONTINUE READING