Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells
@article{Deisseroth2004ExcitationNeurogenesisCI, title={Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells}, author={Karl Deisseroth and Sheela Singla and Hiroki Toda and Michelle Monje and Theo D. Palmer and Robert C. Malenka}, journal={Neuron}, year={2004}, volume={42}, pages={535-552} }
624 Citations
GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor Cells
- BiologyNeuron
- 2005
A diametric mode of neuronal circuitry-neurogenesis coupling in the adult hippocampus via parvalbumin interneurons
- Biology
- 2014
A potential role for PV+ neuron-mediated GABA signaling as a key neuronal activity sensor that translates animal's experience into regulation of adult hippocampal neurogenesis is discussed.
Mature neurons modulate neurogenesis through chemical signals acting on neural stem cells
- BiologyDevelopment, growth & differentiation
- 2016
The existing data on this type of regulation from the three best characterized germinal niches in the adult nervous system: the subventricular zone, the hippocampal subgranular zone, and the carotid body are discussed.
Glutamate as a modulator of embryonic and adult neurogenesis.
- BiologyCurrent topics in medicinal chemistry
- 2006
Glu homeostasis is altered under these pathological circumstances, implying that therapeutic treatments mediating Glu signaling might be useful to increase neuronal replacement after cell loss in the brain.
Activity-Dependent Regulation of the Early Phase of Adult Hippocampal Neurogenesis
- Biology, Psychology
- 2011
This chapter proposes a possible involvement of activity-dependent regulation of the fate of neural stem/progenitor cells in enhanced hippocampal neurogenesis, and reports how hippocampal activity affects the generation of new neurons, even at the early phase of adult hippocampal Neurogenesis.
Glial cells in adult neurogenesis
- BiologyGlia
- 2012
The question arises in how far regionalization of both the glia‐like precursor cells as well as of the glial cells determines site‐specific “neurogenic permissiveness” in the two neurogenic regions of the adult brain.
A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus.
- Biology, PsychologyCell reports
- 2021
Compensatory Neurogenesis in the Injured Adult Brain
- Biology
- 2012
The occurrence of neurogenesis, defined as the generation of new neurons, has become well established in the adult mammalian brain, including the human brain over the last two decades. Neurogenesis…
Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells
- BiologyPloS one
- 2013
It is found that the induction of hippocampal LTP significantly facilitates proliferation/survival and neuronal differentiation of both endogenous neural progenitor cells (NPCs) and exogenously transplanted NSCs in the hippocampus in rats, and suggests that pre-conditioning of the host brain receiving area with a LTP-inducing deep brain stimulation protocol prior to NSC transplantation may increase the likelihood of success.
Regulation of Adult Neurogenesis: Factors Affecting the Production and Development of New Neurons
- Biology, Psychology
- 2012
This study examined the role of a subtype of GABAA receptors that contains the δ subunit (δGABAAR) in the regulation of adult hippocampal neurogenesis and reported results that indicate a key role for δ GABAAR in activity-dependentregulation of adult neuroGenesis.
References
SHOWING 1-10 OF 124 REFERENCES
The Adult Rat Hippocampus Contains Primordial Neural Stem Cells
- BiologyMolecular and Cellular Neuroscience
- 1997
The ability to genetically mark and clone normal diploid hippocampal progenitors provides the first definitive evidence that multipotent neural stem cells exist outside of the adult striatal subventricular zone and supports the hypothesis that FGF-2-responsive neural stem Cells may be broadly distributed in the adult brain.
Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS
- BiologyThe Journal of Neuroscience
- 1999
The recruitment of similar FGF-2-responsive cells from the adult optic nerve, a structure well isolated from the neurogenic zones within the brain, confirmed that neuron-competent precursors naturally exist in widely divergent tissues of the adult brain.
Stem cells from the adult human brain develop into functional neurons in culture.
- BiologyExperimental cell research
- 2003
Identification of neural stem cells in the adult vertebrate brain
- BiologyBrain Research Bulletin
- 2002
Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
- BiologyNature
- 1996
It is found that grafts into neurogenic, but not non-neurogenic sites, showed neuronal differentiation, and AHPs grafted in the rostral migratory pathway migrated into the olfactory bulb, differentiating into tyrosine-hydroxylase-positive neurons, a non-hippocampus phenotype.
Adult Rodent Neurogenic Regions: The Ventricular Subependyma Contains Neural Stem Cells, But the Dentate Gyrus Contains Restricted Progenitors
- BiologyThe Journal of Neuroscience
- 2002
Stem cells can be isolated from hippocampus-adjacent regions of subependyma, but the adult DG proper does not contain a population of resident neural stem cells, suggesting that neuron-specific progenitors and not multipotential stem cells are the source of newly generated DG neurons throughout adulthood.
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
- BiologyThe Journal of Neuroscience
- 2001
It is shown that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells.
Neurogenesis in the adult is involved in the formation of trace memories
- Biology, PsychologyNature
- 2001
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time.
Astroglia induce neurogenesis from adult neural stem cells
- BiologyNature
- 2002
These findings reinforce the emerging view that astrocytes have an active regulatory role—rather than merely supportive roles traditionally assigned to them—in the mature central nervous system.
Simulated Apoptosis/Neurogenesis Regulates Learning and Memory Capabilities of Adaptive Neural Networks
- Biology, PsychologyNeuropsychopharmacology
- 2004
These simulations predict that apoptotic and neurogenic events could act together to produce specific learning and memory effects beyond those provided by ongoing mechanisms of connection plasticity in neuronal populations.