Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.

@article{Souchet2014ExcitationinhibitionBA,
  title={Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.},
  author={Benoit Souchet and Faycal Guedj and Ignasi Sah{\'u}n and Arnaud Duchon and Fabrice Daubigney and Anne Badel and Yuchio Yanagawa and Mar{\'i}a Jos{\'e} Barallobre and Mara Dierssen and Eugene Yu and Yann H{\'e}rault and Mariona Arbones and Nathalie Janel and Nicole Cr{\'e}au and Jean Maurice Delabar},
  journal={Neurobiology of disease},
  year={2014},
  volume={69},
  pages={65-75}
}
Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine kinase DYRK1A, as a candidate for inducing cognitive dysfunction. Here, consequences of alterations in Dyrk1a dosage were assessed in mouse models with varying copy numbers of Dyrk1a: mBACtgDyrk1a, Ts65Dn and Dp(16)1Yey (with 3 gene copies) and… CONTINUE READING
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