Excitability changes of somatic and viscero-somatic nociceptive reflexes in the decerebrate-spinal rabbit: role of NMDA receptors.

Abstract

1. Wind-up (frequency-dependent potentiation of the responses of spinal neurones to stimulation of unmyelinated afferents) and other N-methyl-D-aspartate (NMDA) receptor-mediated phenomena have been proposed as key mechanisms underlying persistent pain states. In this study we have compared wind-up in visceral and somatic nociceptive pathways to examine the… (More)

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