Excision repair of O6-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia coli.

Abstract

O6-methylguanine (O6-methylG) is believed to be the premutagenic lesion responsible for mutational activation of the H-ras proto-oncogene in rats treated with N-methyl-N-nitrosourea (MNU). Research on the repair of O6-methylG has primarily focused on the methyltransferases. Potentially, other repair proteins may be involved in repair of O6-methylG. We have… (More)

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@article{Rossi1989ExcisionRO, title={Excision repair of O6-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia coli.}, author={Stefano Rossi and Matthew Conrad and J. M. Voigt and Michael D. Topal}, journal={Carcinogenesis}, year={1989}, volume={10 2}, pages={373-7} }