Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A.

@article{Ma2009ExchangePA,
  title={Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A.},
  author={Nan Ma and Ted Abel and Pepe J. Hernandez},
  journal={Learning & memory},
  year={2009},
  volume={16 6},
  pages={367-70}
}
It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA… CONTINUE READING