Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein

@article{Baek2002ExchangeON,
  title={Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-$\kappa$B and $\beta$-Amyloid Precursor Protein},
  author={Sung Hee Baek and Kenneth a. Ohgi and David W. Rose and Edward H. Koo and Christopher K. Glass and Michael G. Rosenfeld},
  journal={Cell},
  year={2002},
  volume={110},
  pages={55-67}
}

Figures from this paper

New Molecular Bridge between RelA/p65 and NF-κB Target Genes via Histone Acetyltransferase TIP60 Cofactor*
TLDR
The results suggest that TIP60 is involved in the NF-κB pathway through protein interaction with RelA/p65 and that it modulates the transcriptional activity of RelA /p65 in NF-σκB-dependent gene expression.
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.
  • S. Ogawa, J. Lozach, C. Glass
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Investigation of endogenous transcriptional programs regulated by N coR in macrophages reveals that NCoR acts as a transcriptional checkpoint for activator protein (AP)-1-dependent gene networks that regulate diverse biological processes including inflammation, cell migration, and collagen catabolism, with loss of N CoR.
JNK-interacting protein-1 promotes transcription of Aβ protein precursor but not Aβ precursor-like proteins, mechanistically different than Fe65
TLDR
It is reported that AID in combination with Janus kinase interacting protein-1 (JIP-1) can activate gene expression and this activity for the AID fragment may help explain the unique functions of AβPP relative to its other family members, and changes in gene expression found in Alzheimer's disease.
IκBα and p65 Regulate the Cytoplasmic Shuttling of Nuclear Corepressors: Cross-talk between Notch and NFκB Pathways
TLDR
Notch and NFκB pathways are key regulators of numerous cellular events such as proliferation, differentiation, or apoptosis and cytoplasmic sequestration of p65 by IκBα is sufficient to both translocate nuclear corepressors SMRT/N-CoR to the cy toplasm and upregulate transcription of Notch-dependent genes.
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
TLDR
Data establish a role for APP in nuclear signaling, and suggest that therapeutic strategies designed to modulate the cleavage of APP affect AICD-dependent signaling.
A γ-Secretase-independent Mechanism of Signal Transduction by the Amyloid Precursor Protein*
TLDR
It is shown that APP and Fe65 activate transcription through a Gal4-Tip60 reporter in presenilin-1/2-deficient cells lacking generation of AICD and that APP recruited Tip60 to membrane compartments and may signal to the nucleus by a γ-secretase-independent mechanism that involves membrane sequestration and phosphorylation of Tip60.
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation*
TLDR
The data suggest that transcriptional transactivation by APP and Notch may involve distinct mechanisms; whereas the Notch intracellular domain directly functions in the nucleus, the AICD acts indirectly by activating Fe65.
Regulation of distinct biological activities of the NF-κB transcription factor complex by acetylation
Although the proximal cytoplasmic signaling events that control the activation of the NF-κB transcription factor are understood in considerable detail, the subsequent intranuclear events that
...
...

References

SHOWING 1-10 OF 82 REFERENCES
A Novel Nuclear Receptor Corepressor Complex, N-CoR, Contains Components of the Mammalian SWI/SNF Complex and the Corepressor KAP-1*
TLDR
The results suggest that N-CoR is found in distinct multiprotein complexes, which are involved in multiple pathways of transcriptional repression.
The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators
TLDR
Data implicate Bcl-3 as an adaptor between NF-κB p50/p52 and other transcription regulators and suggest that its gene activation function may at least in part be due to recruitment of the Tip60 histone actetylase.
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
TLDR
This work reports the isolation of a novel SMRT-containing complex from HeLa cells that contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness and contains HDAC3, a histone deacetylase not previously thought to interact with SMRT.
Novel NEMO/IκB Kinase and NF-κB Target Genes at the Pre-B to Immature B Cell Transition*
TLDR
The vast majority of the up-modulated genes and an unexpected class of repressed genes were all novel targets of this signaling pathway, encoding transcription factors, receptors, extracellular ligands, and intracellular signaling factors.
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it
The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner*
TLDR
The results demonstrate that the cytoplasmic domain of APP is a highly labile fragment that is stabilized by forming complexes with Fe65 and can then enter the nucleus in neurons and non-neural cells and strongly support the hypothesis that APP signals in the nucleusIn a manner analogous to the function of Notch.
Molecular determinants of nuclear receptor-corepressor interaction.
TLDR
A model in which discrimination of the different lengths of the coactivator and corepressor interaction helices by the nuclear receptor AF2 motif provides the molecular basis for the exchange of coactivators for corepressors is proposed, with ligand-dependent formation of the charge clamp that stabilizes LXXLL binding sterically inhibiting interaction of the extended core Pressor helix.
...
...