Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer.

@article{Timmerman2006ExcessiveTW,
  title={Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer.},
  author={Robert D. Timmerman and Ronald C McGarry and Constantin Yiannoutsos and Lech Papiez and Kathy Tudor and Jill Deluca and Marvene M Ewing and Ramzi E. Abdulrahman and Colleen M. Desrosiers and Mark S Williams and James Fletcher},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 30},
  pages={4833-9}
}
PURPOSE Surgical resection is standard therapy in stage I non-small-cell lung cancer (NSCLC); however, many patients are inoperable due to comorbid diseases. Building on a previously reported phase I trial, we carried out a prospective phase II trial using stereotactic body radiation therapy (SBRT) in this population. PATIENTS AND METHODS Eligible patients included clinically staged T1 or T2 (< or = 7 cm), N0, M0, biopsy-confirmed NSCLC. All patients had comorbid medical problems that… CONTINUE READING
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