Excessive prolongation of the bleeding time by aspirin in essential thrombocythemia is related to a decrease of large von Willebrand factor multimers in plasma

@article{Genderen1997ExcessivePO,
  title={Excessive prolongation of the bleeding time by aspirin in essential thrombocythemia is related to a decrease of large von Willebrand factor multimers in plasma},
  author={Perry J. J. van Genderen and H. H. D. M. van Vliet and Frans J. Prins and D. van de Moesdijk and Roel van Strik and Freek J. Zijlstra and Ulrich Budde and Jan Jacques Michiels},
  journal={Annals of Hematology},
  year={1997},
  volume={75},
  pages={215-220}
}
 Patients with essential thrombocythemia (ET), who frequently have bleeding complications, may manifest an excessive prolongation of the bleeding time (BT) after ingestion of aspirin (ASA). The reason for this excessive prolongation of the BT is unknown, but it is attributed to qualitative platelet defects. Since patients with ET may also have acquired abnormalities of plasma and platelet von Willebrand factor (vWF), we questioned whether the excessive prolongation of the BT by ASA was related… CONTINUE READING

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Prevention and treatment of thrombotic complications in essential thrombocythemia: efficacy and safety of aspirin

  • P Van Genderen, P Mulder, M Waleboer, D van de Moesdijk, J Michiels
  • Br J Haematol
  • 1997
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