Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia

@article{Page2000ExcessivePS,
  title={Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia},
  author={Nigel M. Page and Russell J. Woods and Sheila M. Gardiner and Khomsorn Lomthaisong and Richard T. Gladwell and David J Butlin and Isaac T. Manyonda and Philip J. Lowry},
  journal={Nature},
  year={2000},
  volume={405},
  pages={797-800}
}
Pre-eclampsia is a principal cause of maternal morbidity and mortality, affecting 5–10% of first pregnancies worldwide. Manifestations include increased blood pressure, proteinuria, coagulopathy and peripheral and cerebral oedema. Although the aetiology and pathogenesis remain to be elucidated, the placenta is undoubtedly involved, as termination of pregnancy eradicates the disease. Here we have cloned a complementary DNA from human placental messenger RNA encoding a precursor protein of 121… CONTINUE READING