Excessive opioid use and the development of chronic migraine

@article{Bigal2009ExcessiveOU,
  title={Excessive opioid use and the development of chronic migraine},
  author={M. Bigal and R. Lipton},
  journal={PAIN{\textregistered}},
  year={2009},
  volume={142},
  pages={179-182}
}
Migraine ranks among the world’s 20 most disabling health problems [30], and is the most common neurologic disorder in the developed countries, affecting over 30 million U.S. residents [21]. Long considered a chronic disorder with a benign course, recent research demonstrates that a subgroup worsens over time [6,26]. Clinically, progression is characterized by an increasing frequency of headaches, sometimes with evolution from episodic to chronic migraine (CM). CM is defined as a type of… Expand
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