Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation.

@article{Jang2007ExcessiveNO,
  title={Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation.},
  author={E. Jang and Chang-Shin Park and Sung-Keun Lee and J. Pie and Ju-Hee Kang},
  journal={Life sciences},
  year={2007},
  volume={80 7},
  pages={
          609-17
        }
}
The mechanisms of leptin resistance observed in most cases of human obesity are poorly understood. Therefore, we evaluated the effects of nitric oxide (NO) on the leptin-induced activation of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathways and on the leptin receptor (LEPR) expression using SH-SY5Y cells. Here, we show that the NO donor spermine/NONOate inhibited leptin-induced activation of STAT3 in vitro. The inhibition of leptin-mediated STAT3… Expand
Leptin Potentiates Endothelium-Dependent Relaxation by Inducing Endothelial Expression of Neuronal NO Synthase
Effects of chronic leptin administration on nitric oxide production and immune responsiveness of greenfinches.
JAK redux: a second look at the regulation and role of JAKs in the heart.
  • M. Kurdi, G. Booz
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • 2009
The Cdk5/p35 Kinases Modulate Leptin-Induced STAT3 Signaling
Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells.
...
1
2
3
...

References

SHOWING 1-10 OF 42 REFERENCES
Nitric oxide and thiol redox regulation of Janus kinase activity.
...
1
2
3
4
5
...