Excessive interleukin-15 transpresentation endows NKG2D+CD4+ T cells with innate-like capacity to lyse vascular endothelium in granulomatosis with polyangiitis (Wegener's).

@article{Menthon2011ExcessiveIT,
  title={Excessive interleukin-15 transpresentation endows NKG2D+CD4+ T cells with innate-like capacity to lyse vascular endothelium in granulomatosis with polyangiitis (Wegener's).},
  author={Mathilde de Menthon and Marion Lambert and Elsa Guiard and Sara Tognarelli and B Bienvenu and Alexandre Karras and Lo{\"i}c Guillevin and Sophie Caillat-Zucman},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 7},
  pages={2116-26}
}
OBJECTIVE Granulomatosis with polyangiitis (Wegener's) (GPA) is a rare systemic vasculitis of unknown etiology. Contribution of T cell-mediated immunity is suggested by the presence of granulomatous inflammation and T cell infiltrates in different tissues. We undertook this study to determine whether CD4+ T cells aberrantly expressing the NKG2D activating receptor might participate in the pathophysiology of the disease. METHODS We performed a detailed phenotype and functional analysis of CD4… CONTINUE READING
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