Excessive insulin secretion in Japanese schizophrenic patients treated with antipsychotics despite normal fasting glucose levels.

@article{Sugai2012ExcessiveIS,
  title={Excessive insulin secretion in Japanese schizophrenic patients treated with antipsychotics despite normal fasting glucose levels.},
  author={Takuro Sugai and Yutaro Suzuki and Naoki Fukui and Junzo Watanabe and Shin Ono and Nobuto Tsuneyama and Toshiyuki Someya},
  journal={Journal of clinical psychopharmacology},
  year={2012},
  volume={32 6},
  pages={750-5}
}
The development of impaired glucose tolerance induced by antipsychotics (APs) is of concern as a serious adverse effect of psychiatric drug therapy. However, the mechanism by which APs cause dysfunction of the glucose-insulin response is not fully understood. Recent studies have shown that patients treated with APs for schizophrenia were more likely to exhibit impaired glucose tolerance after a glucose load compared with healthy control subjects, even if fasting glucose levels were within the… CONTINUE READING