Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

@article{Donthamsetty2011ExcessiveHO,
  title={Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.},
  author={Shashikiran Donthamsetty and Vishakha S. Bhave and Corrine S Kliment and William C. Bowen and Wendy M. Mars and Aaron W Bell and Rachel J. E. Stewart and Anne V Orr and Chuanyue Wu and George K Michalopoulos},
  journal={Hepatology},
  year={2011},
  volume={53 2},
  pages={
          587-95
        }
}
UNLABELLED TCBOPOP (1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene) an agonist of the constitutive androstane receptor (CAR), produces rapid hepatocyte hyperplasia and hepatomegaly in the absence of hepatic injury. In this study we demonstrate that integrin-linked kinase (ILK), which is involved in transmission of the extracellular matrix (ECM) signaling by way of integrin receptors, plays an important role in regulating TCPOBOP-induced proliferation of hepatocytes and hepatomegaly. Hepatocyte… CONTINUE READING
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