Excessive glutamate receptor 1 immunoreactivity in adult Down syndrome brains.

Abstract

We studied the immunohistochemical localization of the glutamate receptor subunits GluR1, GluR2/3, and GluR4 in brains of Down syndrome patients and of normal controls. In cerebral cortex of both the control and Down syndrome patients, weak GluR1 immunoreactivity was observed in the cytoplasm of neurons, especially pyramidal neurons, after 34 weeks of… (More)

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