Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response

@article{PerezPozo2010ExcessiveFI,
  title={Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response},
  author={S. E. Perez-Pozo and J. Schold and T. Nakagawa and L. S{\'a}nchez-Lozada and R. Johnson and J. L. Lillo},
  journal={International Journal of Obesity},
  year={2010},
  volume={34},
  pages={454-461}
}
Background:Excessive fructose intake causes metabolic syndrome in animals and can be partially prevented by lowering the uric acid level. We tested the hypothesis that fructose might induce features of metabolic syndrome in adult men and whether this is protected by allopurinol.Methods:A randomized, controlled trial of 74 adult men who were administered 200 g fructose daily for 2 weeks with or without allopurinol. Primary measures included changes in ambulatory blood pressure (BP), fasting… Expand
250 Citations

Paper Mentions

Interventional Clinical Trial
Studies in animals have found that allopurinol can markedly improve fructose induced metabolic syndrome. In this study we test the hypothesis that allopurinol may lower BP… Expand
ConditionsMetabolic Syndrome
InterventionDrug
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