Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response
@article{PerezPozo2010ExcessiveFI, title={Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response}, author={S. E. Perez-Pozo and J. Schold and T. Nakagawa and L. S{\'a}nchez-Lozada and R. Johnson and J. L. Lillo}, journal={International Journal of Obesity}, year={2010}, volume={34}, pages={454-461} }
Background:Excessive fructose intake causes metabolic syndrome in animals and can be partially prevented by lowering the uric acid level. We tested the hypothesis that fructose might induce features of metabolic syndrome in adult men and whether this is protected by allopurinol.Methods:A randomized, controlled trial of 74 adult men who were administered 200 g fructose daily for 2 weeks with or without allopurinol. Primary measures included changes in ambulatory blood pressure (BP), fasting… Expand
Paper Mentions
Interventional Clinical Trial
Studies in animals have found that allopurinol can markedly improve fructose induced
metabolic syndrome. In this study we test the hypothesis that allopurinol may lower BP… Expand
Conditions | Metabolic Syndrome |
---|---|
Intervention | Drug |
250 Citations
Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress
- Medicine
- BMC Nephrology
- 2018
- 9
A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial.
- Medicine
- Journal of the American Society of Hypertension : JASH
- 2015
- 39
Fructose‐Containing Sugars Do Not Raise Blood Pressure or Uric Acid at Normal Levels of Human Consumption
- Medicine
- Journal of clinical hypertension
- 2015
Dietary fructose and risk of metabolic syndrome in adults: Tehran Lipid and Glucose study
- Medicine
- Nutrition & metabolism
- 2011
- 21
Direct renal effects of a fructose-enriched diet: interaction with high salt intake.
- Chemistry, Medicine
- American journal of physiology. Regulatory, integrative and comparative physiology
- 2015
- 15
- PDF
Differences in acute metabolism of fructose between hemodialysis patients and healthy subjects
- Biology, Medicine
- Scandinavian journal of clinical and laboratory investigation
- 2013
- 8
Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease.
- Medicine
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- 2012
- 73
- PDF
Uric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic Syndrome
- Medicine
- Cardiorenal Medicine
- 2013
- 107
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
- Medicine
- Nutrition & Metabolism
- 2012
- 110
- PDF
Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.
- Medicine
- Journal of the American Society of Hypertension : JASH
- 2016
- 7
References
SHOWING 1-10 OF 48 REFERENCES
A causal role for uric acid in fructose-induced metabolic syndrome.
- Biology, Medicine
- American journal of physiology. Renal physiology
- 2006
- 942
- PDF
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
- Biology, Medicine
- Endocrine reviews
- 2009
- 411
- PDF
Nocturnal hypertension in mice consuming a high fructose diet
- Biology, Medicine
- Autonomic Neuroscience
- 2006
- 106
Fructose ingestion acutely elevates blood pressure in healthy young humans.
- Medicine
- American journal of physiology. Regulatory, integrative and comparative physiology
- 2008
- 209
- PDF
The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension
- Medicine
- Molecular and Cellular Biochemistry
- 2009
- 295
Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose.
- Medicine
- The American journal of clinical nutrition
- 1983
- 165
Combination of Captopril and Allopurinol Retards Fructose-Induced Metabolic Syndrome
- Medicine
- American Journal of Nephrology
- 2009
- 34
Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men.
- Chemistry, Medicine
- The Journal of nutrition
- 1983
- 114
Female rats are protected against fructose-induced changes in metabolism and blood pressure.
- Biology, Medicine
- American journal of physiology. Heart and circulatory physiology
- 2002
- 151
- PDF
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
- Medicine
- Journal of the American Society of Nephrology : JASN
- 2007
- 110
- PDF