Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.

@article{Takabayashi2013ExcessiveFD,
  title={Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.},
  author={Tetsuji Takabayashi and Atsushi Kato and Anju Tripathi Peters and Kathryn E. Hulse and Lydia A Suh and Roderick G Carter and James E. Norton and Leslie C. Grammer and Seong- Ho Cho and Bruce K. Tan and Rakesh Kumar Chandra and David B. Conley and Robert C. Kern and Shigeharu Fujieda and Robert P. Schleimer},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={187 1},
  pages={49-57}
}
RATIONALE Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. OBJECTIVES We hypothesized that formation of a fibrin mesh retains plasma proteins in NPs. We assessed the fibrin deposition and expression of the components of the fibrinolytic system in patients with chronic rhinosinusitis (CRS). METHODS We assessed… CONTINUE READING
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