• DOI:10.1016/S0140-6736(02)07594-3
Corpus ID: 12319751

Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels

@article{Jefferson2002ExcessiveEC,
  title={Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels},
  author={J. A. Jefferson and E. Escudero and M. Hurtado and J. Pando and R. Tapia and E. Swenson and J. Prchal and GeorgeE. Schreiner and R. Schoene and Abdias Hurtoado and Richard J. Johnson},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={407-408}
}

• J. A. Jefferson, E. Escudero, +8 authors Richard J. Johnson
• Published 2002
• Medicine
• The Lancet

In a subset of high-altitude dwellers, the appropriate erythrocytotic response becomes excessive and can result in chronic mountain sickness. We studied men with (study group) and without excessive erythrocytosis (packed-cell volume >65%) living in Cerro de Pasco, Peru (altitude 4300 m), and compared them with controls living in Lima, Peru (at sea-level). Toxic serum cobalt concentrations were detected in 11 of 21 (52%) study participants with excessive erythrocytosis, but were undetectable in… Expand

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