Excessive doses of cerulein stimulate pancreatic growth in suckling rats but damage the pancreas of weaned rats.

@article{Papp1988ExcessiveDO,
  title={Excessive doses of cerulein stimulate pancreatic growth in suckling rats but damage the pancreas of weaned rats.},
  author={M. Papp and I. Dobronyi and G. Varga},
  journal={Biology of the neonate},
  year={1988},
  volume={54 6},
  pages={
          339-46
        }
}
The cerulein-stimulated pancreatic growth response was evaluated in 4- and 11-day-old female suckling CFY rats and compared with the pancreatic response of cerulein-treated 24-day-old weaned rats. Cerulein was given subcutaneously in saline in 1-, 10- and 100-micrograms/kg doses t.i.d. The increase in pancreatic DNA content was regarded as an index for hyperplasia, and the increase in pancreatic weight, protein content and enzyme activity related to milligrams of DNA as an index for hypertrophy… Expand