Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology.

@article{Ikeda2013ExcessiveAE,
  title={Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology.},
  author={Keiko Ikeda and Tsuyoshi Baba and Hiroko Noguchi and Kunihiko Nagasawa and Toshiaki Endo and Tamotsu Kiya and Tsuyoshi Saito},
  journal={Human reproduction},
  year={2013},
  volume={28 2},
  pages={453-61}
}
STUDY QUESTION Does administration of androgen to female-to-male transsexual persons (FTMs) of reproductive age induce polycystic ovary (PCO) morphology? SUMMARY ANSWER Administration of high-dose androgen to women causes pathognomonic changes to the ovarian cortex and stroma that resemble Stein-Leventhal syndrome but it does not induce PCO morphology. WHAT IS KNOWN ALREADY Androgen is thought to play a key role in follicular development and to be involved in the pathophysiology of… CONTINUE READING