Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1

@article{Salehi2008ExcessiveIN,
  title={Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1},
  author={Albert Salehi and Sandra Meidute Abaraviciene and Javier Jimenez-Feltstrom and C. -G. {\"O}stenson and Suad Efend{\'i}c and Ingmar Lundquist},
  journal={PLoS ONE},
  year={2008},
  volume={3}
}
BACKGROUND A distinctive feature of type 2 diabetes is inability of insulin-secreting beta-cells to properly respond to elevated glucose eventually leading to beta-cell failure. We have hypothesized that an abnormally increased NO production in the pancreatic islets might be an important factor in the pathogenesis of beta-cell dysfunction. PRINCIPAL FINDINGS We show now that islets of type 2 spontaneous diabetes in GK rats display excessive NO generation associated with abnormal iNOS… CONTINUE READING

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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