Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons*

@article{Nakamura2001ExcessiveHB,
  title={Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons*},
  author={M. Nakamura and A. Barber and D. Antonetti and K. Lanoue and K. Robinson and M. Buse and T. Gardner},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={43748 - 43755}
}
  • M. Nakamura, A. Barber, +4 authors T. Gardner
  • Published 2001
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • In addition to microvascular abnormalities, neuronal apoptosis occurs early in diabetic retinopathy, but the mechanism is unknown. Insulin may act as a neurotrophic factor in the retina via the phosphoinositide 3-kinase/Akt pathway. Excessive glucose flux through the hexosamine biosynthetic pathway (HBP) is implicated in the development of insulin resistance in peripheral tissues and diabetic complications such as nephropathy. We tested whether increased glucose flux through the HBP perturbs… CONTINUE READING
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