Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.

@article{Lin2007ExcessRR,
  title={Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.},
  author={Z. P. Lin and Michael F. Belcourt and Rocco Carbone and Jana S Eaton and Philip G Penketh and Gerald S Shadel and Joseph G. Cory and Alan C. Sartorelli},
  journal={Biochemical pharmacology},
  year={2007},
  volume={73 6},
  pages={760-72}
}
Ribonucleotide reductase (RNR), which consists of R1 and R2 subunits, catalyzes a key step of deoxyribonucleoside triphosphate (dNTP) synthesis for DNA replication and repair. The R2 subunit is controlled in a cell cycle-specific manner for timely DNA synthesis and is negatively regulated by p53 in response to DNA damage. Herein we demonstrate that the presence of excess R2 subunits in p53(-/-) HCT-116 human colon cancer cells protects against DNA damage and replication stress. siRNA-mediated… CONTINUE READING

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Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress .
Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress .
Ribonucleotide ReductaseGene product plays role in biological processDNA Replication
Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress .
Ribonucleotide reductase ( RNR ) , which consists of R1 and R2 subunits , catalyzes a key step of deoxyribonucleoside triphosphate ( dNTP ) synthesis for DNA replication and repair .
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