Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster.

@article{Thornton2005ExcessOA,
  title={Excess of amino acid substitutions relative to polymorphism between X-linked duplications in Drosophila melanogaster.},
  author={Kevin R. Thornton and Manyuan Long},
  journal={Molecular biology and evolution},
  year={2005},
  volume={22 2},
  pages={273-84}
}
We have obtained sequence polymorphism data from 13 genes belonging to 5 gene families in Drosophila melanogaster where the K(a)/K(s) between copies is greater than 1. Twelve of these 13 loci are X-linked. In general, there is evidence of purifying selection in all families, as inferred both from levels of silent and replacement variation and insertion/deletion variation, suggesting that the loci are likely functional. Shared polymorphisms indicative of gene conversion between paralogs are rare… CONTINUE READING
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