Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation.

@article{Maury2013ExcessOO,
  title={Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation.},
  author={Julien Jean Pierre Maury and Ken Kwok-Keung Chan and Lu Zheng and Muriel Bardor and Andre Boon-Hwa Choo},
  journal={Stem cell research},
  year={2013},
  volume={11 2},
  pages={
          926-37
        }
}
O-linked-N-acetylglucosamine (O-GlcNAc), a post translational modification, has emerged as an important cue in controlling key cell mechanisms. Here, we investigate O-GlcNAc's role in the maintenance and differentiation of human pluripotent stem cells (hPSC). We reveal that protein expression of O-GlcNAc transferase and hydrolase both decreases during hPSC differentiation. Upregulating O-GlcNAc with O-GlcNAc hydrolase inhibitors has no significant effect on either the maintenance of… CONTINUE READING
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