Excess mortality in acromegaly.

  title={Excess mortality in acromegaly.},
  author={Ian M. Holdaway},
  journal={Hormone research},
  volume={68 Suppl 5},
BACKGROUND Increased production of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in patients with acromegaly is associated with a twofold increase in mortality compared with the general population. The range of standardised mortality rates in various studies ranges from 1.2 to 3.6. PREDICTORS OF MORTALITY Multivariate analysis has indicated that post-treatment serum GH levels and, in a number of studies, serum IGF-I levels are the most powerful predictors of outcome. Normal IGF… CONTINUE READING


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