Excess lunatic fringe causes cranial neural crest over-proliferation.

  title={Excess lunatic fringe causes cranial neural crest over-proliferation.},
  author={Christian Nellemann and Maria Elena De Bellard and Meyer Barembaum and E M Laufer and Marianne Bronner-Fraser},
  journal={Developmental biology},
  volume={235 1},
Lunatic fringe is a vertebrate homologue of Drosophila fringe, which plays an important role in modulating Notch signaling. This study examines the distribution of chick lunatic fringe at sites of neural crest formation and explores its possible function by ectopic expression. Shortly after neural tube closure, lunatic fringe is expressed in most of the neural tube, with the exception of the dorsal midline containing presumptive neural crest. Thus, there is a fringe/non-fringe border at the… CONTINUE READING

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