Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury

@article{Tan2013ExcessIM,
  title={Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury},
  author={Terrence Huat Hin Tan and Darrell Henry Crawford and Lesley A Jaskowski and V Nathan Subramaniam and Andrew D Clouston and Denis I. Crane and Kim Bridle and Gregory J Anderson and Linda Maria Fletcher},
  journal={Laboratory Investigation},
  year={2013},
  volume={93},
  pages={1295-1312}
}
Endoplasmic reticulum (ER) stress is an important pathogenic mechanism for alcoholic (ALD) and nonalcoholic fatty liver disease (NAFLD). Iron overload is an important cofactor for liver injury in ALD and NAFLD, but its role in ER stress and associated stress signaling pathways is unclear. To investigate this, we developed a murine model of combined liver injury by co-feeding the mildly iron overloaded, the hemochromatosis gene-null (Hfe−/) mouse ad libitum with ethanol and a high-fat diet (HFD… CONTINUE READING

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