Excess histone levels mediate cytotoxicity via multiple mechanisms.

  title={Excess histone levels mediate cytotoxicity via multiple mechanisms.},
  author={Rakesh K. Singh and Dun Liang and Ugander Reddy Gajjalaiahvari and Marie-Helene Miquel Kabbaj and Johanna Paik and Akash Gunjan},
  journal={Cell cycle},
  volume={9 20},
The accumulation of excess histone proteins in cells has deleterious consequences such as genomic instability in the form of excessive chromosome loss, enhanced sensitivity to DNA damaging agents and cytotoxicity. Hence, the synthesis of histone proteins is tightly regulated at multiple steps and transcriptional as well as posttranscriptional regulation of histone proteins is well established. Additionally, we have recently demonstrated that histone protein levels are regulated… CONTINUE READING

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