Excess histidine enzymes cause AICAR-independent filamentation in Escherichia coli

@article{Frandsen1993ExcessHE,
  title={Excess histidine enzymes cause AICAR-independent filamentation in Escherichia coli},
  author={Niels Frandsen and R D'ari},
  journal={Molecular and General Genetics MGG},
  year={1993},
  volume={240},
  pages={348-354}
}
High-level expression of the hisHAFI genes in Escherichia coli, cloned under the control of an IPTG-inducible promoter, caused filamentation, as previously reported in Salmonella typhimurium. We speculated that this filamentation might be produced by an action of the HisH and HisF enzymes on their product AICAR (amino-imidazole carboxamide riboside 5′-phosphate), a histidine by-product and normal purine precursor, possibly by favouring the formation of ZTP, the triphosphate derivative of AICAR… CONTINUE READING

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