Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice.

@article{Burrows1998ExcessCR,
  title={Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice.},
  author={Heather L. Burrows and Masahiro Nakajima and J. Shonee Lesh and Ki A Goosens and Linda C. Samuelson and Akio Inui and Sally A Camper and Audrey F. Seasholtz},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 7},
  pages={1439-47}
}
Corticotropin-releasing hormone (CRH) is the primary hypothalamic releasing factor that mediates the mammalian stress response. The CRH-binding protein (CRH-BP) is secreted from corticotropes, the pituitary CRH target cells, suggesting that the CRH-BP may modulate hypothalamic-pituitary-adrenal (HPA) axis activity by preventing CRH receptor stimulation. Transgenic mice were generated that constitutively express elevated levels of CRH-BP in the anterior pituitary gland. RNA and protein analyses… CONTINUE READING