Excess Soluble CD40L Contributes to Blood Brain Barrier Permeability In Vivo: Implications for HIV-Associated Neurocognitive Disorders

@inproceedings{Davidson2012ExcessSC,
  title={Excess Soluble CD40L Contributes to Blood Brain Barrier Permeability In Vivo: Implications for HIV-Associated Neurocognitive Disorders},
  author={Donna C. Davidson and Michael P. Hirschman and Anita Wenjing Sun and Meera V. Singh and Karl A. Kasischke and Sanjay B. Maggirwar},
  booktitle={PloS one},
  year={2012}
}
Despite the use of anti-retroviral therapies, a majority of HIV-infected individuals still develop HIV-Associated Neurocognitive Disorders (HAND), indicating that host inflammatory mediators, in addition to viral proteins, may be contributing to these disorders. Consistently, we have previously shown that levels of the inflammatory mediator soluble CD40L (sCD40L) are elevated in the circulation of HIV-infected, cognitively impaired individuals as compared to their infected, non-impaired… CONTINUE READING

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