Excess Mutual Catalysis Is Required for Effective Evolvability
@article{Markovitch2012ExcessMC, title={Excess Mutual Catalysis Is Required for Effective Evolvability}, author={Omer Markovitch and D. Lancet}, journal={Artificial Life}, year={2012}, volume={18}, pages={243-266} }
It is widely accepted that autocatalysis constitutes a crucial facet of effective replication and evolution (e.g., in Eigen's hypercycle model). Other models for early evolution (e.g., by Dyson, Gánti, Varela, and Kauffman) invoke catalytic networks, where cross-catalysis is more apparent. A key question is how the balance between auto- (self-) and cross- (mutual) catalysis shapes the behavior of model evolving systems. This is investigated using the graded autocatalysis replication domain… CONTINUE READING
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References
SHOWING 1-10 OF 71 REFERENCES
Mutations and Lethality in Simulated Prebiotic Networks
- Biology, Medicine
- Journal of Molecular Evolution
- 2009
- 10
Emergence of symbiosis in peptide self-replication through a hypercyclic network
- Biology, Medicine
- Nature
- 1997
- 226
Graded Autocatalysis Replication Domain (GARD): Kinetic Analysis of Self-Replication in Mutually Catalytic Sets
- Chemistry, Medicine
- Origins of life and evolution of the biosphere
- 2004
- 98
- PDF
Compositional genomes: prebiotic information transfer in mutually catalytic noncovalent assemblies.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2000
- 279
- PDF
Lack of evolvability in self-sustaining autocatalytic networks constraints metabolism-first scenarios for the origin of life
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2010
- 132
- Highly Influential
- PDF
The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.
- Biology, Medicine
- Die Naturwissenschaften
- 1977
- 625
- PDF
Coevolution of compositional protocells and their environment
- Biology, Medicine
- Philosophical Transactions of the Royal Society B: Biological Sciences
- 2007
- 33
- PDF
The molecular roots of compositional inheritance.
- Mathematics, Medicine
- Journal of theoretical biology
- 2001
- 62
- PDF
Kinetic Origin of Heredity in a Replicating System with a Catalytic Network
- Chemistry, Medicine
- Journal of biological physics
- 2002
- 9
- PDF
From replicators to reproducers: the first major transitions leading to life.
- Biology, Medicine
- Journal of theoretical biology
- 1997
- 262
- Highly Influential
- PDF